Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation

Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.

BACKGROUND The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly, hepatocyte cell death from bile acid-induced toxicity occurs more frequently from apoptosis than from necrosis. However, both processes appear to involve the mitochondrial membrane permeability transition (MPT). In this study, we ...

Ursodeoxycholic acid

Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem] Indication: The drug reduces cholesterol absorption and is used to dis...

Chemotherapy-associated supravenous hyperpigmentation.

Amlodipine associated hyperpigmentation.

Amlodipine is a potent peripheral and coronary vasodilator with high selectivity for vascular smooth muscle, and is widely used in mild to moderate hypertension, chronic stable angina and vasospastic angina. Its most prevalent side effects are peripheral edema, flushing and headache. Cutaneous adverse reactions associated with amlodipine have been rarely reported. Herein, a male patient is desc...

Tongue hyperpigmentation associated with chemotherapy

W e demonstrate a new hyperpigmentation on the tongue of a 68-year-old female patient who was diagnosed with stage IIA infiltrating ductal carcinoma of the left breast who underwent modified radical mastectomy followed by a triple chemotherapy regimen which consisted of doxorubicin, docetaxel, and cyclophosphamide. The patient developed the tongue hyperpigmentation a few weeks after the initiat...